ABSTRACT
Introduction: -thalassemia is the most frequent single genedisorder in the world. As a result of repeated transfusions,significant hepatic fibrosis develops over time and itsprogression is directly related to degree of iron overload. In thepresent study we investigated the relationship between theextent of hepatocellular injury as reflected by liver functiontests (LFTs) and serum ferritin.Materials and Methods: It was an analytical cohort studycarried out during the time period from January 2017 to June2018 from High Performance Liquid Chromatography (HPLC)confirmed -thalassemia patients, dependant on regular bloodtransfusion.Results: Our study included 58 (58%) male patients and 42(42%) female patients. Level of Hemoglobin and Packed cellvolume (PCV) increased after 6 months of chelation therapycompared to pre-chelation levels. Whereas, the S. Ferritin andLiver enzymes levels decreased after 6 months of initiation ofchelation therapy.Conclusion: High S. ferritin is a sensitive predictor of hepaticdysfunction, hence, it is a good and reliable non-invasivescreening test for iron overload but it is not a good indicator ofdisease progression, as it has low specificity above levels of2500 ng/ml. Combination therapy with deferiprone anddeferasirox is more effective than either drug alone.
ABSTRACT
Introduction: The prevalence of leukemia is known to varythroughout the India. An attempt was made to find out patternof leukemia and its distribution throughout the Ajmer region.Materials and Methods: Samples of 45,391 cases werecollected in Haematology section, Department of Pathology,Jawahar Lal Nehru Medical College, Ajmer during last 2 yearsand 6 months from January 2014 to June 2016. Clinicallysuspected patients were sent for Complete Blood Count,Peripheral Blood Film and bone marrow examination and otherroutine investigations.Results: Most prevalent leukemia was Chronic MyeloidLeukemia 47 cases (35%) and least prevalent is ChronicLymphocytic Leukemia 13 cases (9.7%). Acute leukemia weremore diagnosed in young adult, while chronic leukemia weremore in middle and old age group. Leukemia was found morein male patient (male:female ratio 1.19:1).Conclusion: The commonest leukemia was found to beChronic Myloid Leukemia. Leukemia was more prevalent inmales